Lack of Cross-protection againstBordetella holmesiiafter Pertussis Vaccination

Lack of Cross-protection against Bordetella holmesii after Pertussis Vaccination

Bordetella holmesii, a species closely related to B. pertussis, has been reported sporadically as a cause of whooping cough-like symptoms. To investigate whether B. pertussis-induced immunity is protective against infection with B. holmesii, we conducted an analysis using 11 human respiratory B. holmesii isolates collected during 2005-2009 from a highly B. pertussis-vaccinated population in Mas...

The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial

Background: Despite primary vaccination, infants under six months run a risk of infection with pertussis. Objective: To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. Methods: All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The moth...

Impact of vaccination on epidemiology of diphtheria and pertussis

Whooping cough and diphtheria are vaccine preventable diseases. Diphtheria, due to Corynebacterium diphtheriae or Corynebactium ulcerans, two Gram positive bacteria, is a serious upper respiratory tract disease with high morbidity and mortality rates. Vaccination, via an acellular vaccine composed only of purified, detoxified diphtheria toxin, has significantly reduced the incidence of the dise...

Pertussis vaccination and pregnancy.

TO THE EDITOR—We welcome the contribution of Healy et al [1] on (pre)pregnancy diphtheria, tetanus, and acellular pertussis (dTpa) immunization, as scientific evidence on this topic is increasingly needed to assist countries in their decision-making processes. Pertussis incidence and disease severity is worryingly high in very young infants in countries with high coverage for infant pertussis v...

Vaccination against pertussis.